![]() ![]() In the current study, both transcriptome and metabolome analysis were performed to comprehensively evaluate the underlying mechanism. Using a combination treatment of docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) and bortezomib, it was demonstrated previously that pretreatment with DHA/EPA significantly increased bortezomib chemosensitivity in MM cells. While treatment with the proteasome inhibitor bortezomib substantially increases overall survival of MM patients, acquired drug resistance remains the main challenge for MM treatment. ![]() Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of proteasome activity. ![]()
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